منابع مشابه
Reassessing pattern separation in the dentate gyrus
INTRODUCTION The dentate gyrus (DG) is postulated to be a “pattern separator” (Marr, 1971; Rolls, 1989a,b, 1990; Treves and Rolls, 1994). Yet, the definition of pattern separation has become a haze, with researchers using the term interchangeably to describe computational processes, changes in cell ensemble activity, and even behavioral phenomena (Leutgeb et al., 2007; McHugh et al., 2007; Clel...
متن کاملComputational Pattern Separation Models of Dentate Gyrus Neural Subpopulation in the Hippocampus
Hippocampus is a part of the brain that has an essential role in memory and learning. It is involved in many cognitive and behavioral phenomena, including the pattern separation process: the ability to distinguish patterns with very high similarity. The present study compared the models of pattern separation in the dentate gyrus of the hippocampus and aimed to investigate the significant cel...
متن کاملPattern separation in the human hippocampal CA3 and dentate gyrus.
Pattern separation, the process of transforming similar representations or memories into highly dissimilar, nonoverlapping representations, is a key component of many functions ascribed to the hippocampus. Computational models have stressed the role of the hippocampus and, in particular, the dentate gyrus and its projections into the CA3 subregion in pattern separation. We used high-resolution ...
متن کاملStrong Evidence for Pattern Separation in Human Dentate Gyrus.
UNLABELLED The hippocampus is proposed to be critical in distinguishing between similar experiences by performing pattern separation computations that create orthogonalized representations for related episodes. Previous neuroimaging studies have provided indirect evidence that the dentate gyrus (DG) and CA3 hippocampal subregions support pattern separation by inferring the nature of underlying ...
متن کاملPattern Separation Performance in Parkinson ’ s Disease Suggests Dentate Gyrus
Background: Destruction of dopaminergic neurones decreases hippocampal Dentate Gyrus (DG) neurogenesis in rodents and primates. Post-mortem work in Parkinson’s Disease (PD) patients identified evidence of compromised hippocampal neurogenesis. In both animals and man, difficult discriminations in tests which require discrimination between previously seen objects and closely similar ones (object ...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2009
ISSN: 1662-5153
DOI: 10.3389/conf.neuro.08.2009.09.033